The anatomical and physiological function of peritoneal.docVIP

 PAGE \* MERGEFORMAT 17 The anatomical and physiological function of peritoneal Dendritic cells (Dendritic Cells, DC) in vivo is currently the most powerful professional antigen-presenting cells, has launched T cell-mediated immune response functions. This article describes the DC-induced tumors in the blood’s own tumor-killing activity, transplantation immunology, treatment and prognosis of research. Dendritic cells (Dendritic Cells, DC) is a concern in recent years, oft-professional antigen-presenting cells (Antigen presenting Cells, APC), capable of taking, processing and presenting antigens to start the T cell-mediated immune response. DC in 1973 by Steinman and Cohn found that for the first time. In recent years, on DC differentiation, development and anti-tumor applications are particularly affected by people’s attention. In this paper, the study of blood DC tumor are reviewed. 1 DC-induced tumor-killing activity of its own Choudhury et al [1] reported that chronic myeloid leukemia (CML) chronic phase patients with peripheral blood mononuclear cells and cytokines - granulocyte monocyte colony stimulating factor (CM-CSF), interleukin 4 (IL-4), tumor necrosis factor-α (TNF-α ) after incubated in vitro, resulting in morphology, immune phenotype cells with DC characteristics, fluorescence in situ hybridization (FISH) showed that these cells in the t (9; 22) the existence of what they have from the leukemic cells. Specific function of DC in vitro assay confirmed that these cells have the potential to stimulate lymphocyte proliferation. Leukemia in vitro generated DC to stimulate autologous T cells to produce a strong anti-leukemia cell cytotoxic activity, but the major histocompatibility complex (Major histocompatibility Complex, MHC) matched normal allogeneic bone marrow cells showed a low response. With the DC to stimulate autologous T cells against CML target cells, the cytotoxic activity is IL-2 alone in vitro cultured autologous T cells in amplificat