Therapeutic antibody research project.docVIP

 PAGE \* MERGEFORMAT 21 Therapeutic antibody research project [Abstract] came to the application of monoclonal antibodies from the clinical, experienced a tortuous development process, including genetically engineered antibodies is an important milestone, and accompanied by a series of major technological innovations. The use of antibody engineering technology developed properties and characteristics of different high-performance therapeutic antibodies, such as the enhancement features full-length antibody, transmission cytotoxicity of immunotoxins, antibody and cytokine fusion protein connected, as well as anchoring a variety of receptor bispecific antibodies. This review describes the recent progress in therapeutic antibody engineering. [Keywords:] engineered antibody; therapeutic antibodies; bispecific antibody; effect function Progress and application of new-style engineering antibody used for therapeutic [Abstract] When monoclonal antibody comes into being, it has been an uneven way in its widely clinical applications. But the engineered antibody sets an important milestone with a series of technology renovations. A diversity of engineered antibody forms have been created to improve their efficacy , including enhancing the effector functions of full-length antibodies, delivering toxins to kill cells or cytokines in order to stimulate the immune system, and bispecific antibodies to target multiple receptors and so on. The review almost focuses on this new progress of engineering antibody used for treatment. [Keywords:] engineering antibody; therapeutic antibody; bispecific antibody; effector function Since 1975, application of K  hler and Milstein hybridoma cells produce monoclonal antibodies (monoclonal antibody, mAb) has been the study and application of the mAb obtained considerable progress. As the therapeutic mAb with specificity, can carry other molecular characteristics such as pre-clinical and clinical studies obtained unable t