Tissue-engineered osteochondral complex in Research Progress and Prospects.docVIP

 PAGE \* MERGEFORMAT 20 Tissue-engineered osteochondral complex in Research Progress and Prospects Authors: Yang Qiang, Peng Jiang Lu Shibi reviewed, Yuan Mei [Keywords:] cartilage As materials science, cell biology, biology and bio-reactor mechanical advances in technology, using tissue engineering methods to build a suitable size and shape of the tissue-engineered osteochondral composite body for the repair of osteochondral defects at offers new hope. This paper will review in this area. A stent At present on the body of tissue-engineered osteochondral scaffold design principles are very different, mainly divided into the following four categories: 1.1 stents using only bone, cartilage, partial non-use of stents Namely, direct high-density cartilage cells or cartilage cells directly into the bracket at the top of growing bone in vitro or implanted in vivo to repair bone cartilage composite defects. Wang [1] and other high-density primary porcine chondrocytes were grown to the three kinds of scaffolds P (L) LA, P (D, L) LA, collagen / hydroxyapatite (Col-HA) composite scaffold materials, in vitro using a static closed bioreactor cultured for 7 weeks to build up bone cartilage complex of the cartilage part of the rich in type Ⅱ collagen and glycosaminoglycan (GAG), cartilage and bone scaffolds combined some good. Waldman [2] and so the same with bovine chondrocytes in high-density polyethylene plant to calcium (calcium polypho sphate, CPP) scaffolds in vitro cultivated a successful bone cartilage complex. Kandel [3] and so using the same methods to build bone tissue engineering cartilage complex, in vitro culture for 8 weeks after implantation into sheep distal femoral intercondylar fossa bone cartilage defects, tissue engineering complex and the surrounding bone cartilage bone cartilage bed healed well, and its bio-mechanical properties has been greatly improved. TULI [4] using human bone marrow-derived mesenchymal progenitor cells, induction into