TMP control rat membranous nephropathy in rats_0.docVIP

 PAGE \* MERGEFORMAT 15 TMP control rat membranous nephropathy in rats Of: Tan Zongfeng Luoguang Yan Sun Xingwang Caoling Liang Jing Zhou Wanhong Zoude Ping [Abstract] Objective To explore TMP on cationic bovine serum albumin (C-BSA) membranous nephropathy induced effect and mechanism of prevention and treatment. Methods 30 SD male rats were randomly divided into: normal group, model group, TMP prophylaxis group. In addition to the normal group, the other two groups according to improvement of Border (1), replicated membranous nephropathy rat model, TMP TMP treatment group prevention intervention treatment. official immunization 4 weeks, whichever is greater hamster kidney tissue by light microscopy, electron microscopy and immunofluorescence; take urine and blood tests urinary protein, serum albumin, total cholesterol, triglycerides, creatinine, urea nitrogen and creatinine clearance rate within. Results TMP Group glomerular subepithelial electron dense deposit was reduced, renal pathological damage significantly reduced compared with model group; TMP group serum creatinine, blood urea nitrogen levels compared with the model group were significantly lower (P lt;0.05), while the serum albumin level and model group was significantly higher (P lt;0.05), 24 h urine protein, cholesterol, triglycerides compared with the model group decreased, but the difference was not statistically significant (Pgt; 0.05). Conclusions on the TMP by decreasing glomerular subcutaneous deposition of immune complexes, reduce podocyte injury, glomerular basement membrane thickening and decreased inhibition of serum creatinine, blood urea nitrogen level of protective effect on renal function. [Keywords:] cationic bovine serum albumin; TMP; membranous nephropathy Membranous nephropathy (Membranous nephropathy, MN) is a common glomerular diseases, the main pathological changes of glomerular basement membrane (glomerular basement membrane, GBM) subepithelial immune complex depos