TNF-α anti-tumor mechanism of Progress.docVIP

 PAGE \* MERGEFORMAT 28 TNF-α anti-tumor mechanism of Progress 【Abstract】 TNF-α-induced apoptosis through the TNFR; promote the proliferation and differentiation of immune cells to produce anti-tumor effect; influence local tumor blood vessels, increase the permeability of tumor vascular endothelial cells, promote thrombosis, anti-tumor angiogenesis, resulting in inhibition or cytotoxicity. Keywords: tumor necrosis factor anti-tumor effect of immune cells In 1975, Carswell and others found that BCG vaccination or by bacterial endotoxin in mice infected with serum containing a tumor-bearing animals, can cause hemorrhagic necrosis of tumor tissue material, the substance of a variety of in vitro tumor cell lines with cytotoxic However, no killing effect on normal cells, and this substance called tumor necrosis factor (tumour necrosis factor, TNF). Lienard and other TNF-α by isolated limb perfusion for treatment of limb soft tissue tumors and osteomas made a sensation results. The late 20th century, 90 in Europe, America TNF-α re-affirmed the important role of anti-tumor, setting off a TNF-α in cancer research and cancer treatment in the new chapter. TNF-α has a variety of biological activity of anti-tumor effect of this on their machines to produce a synthesis. 1 TNF structure Natural TNF is a glycoprotein, exists in two forms, namely, TNF-α, TNF-β. TNF-α by LPS-activated monocytes - macrophages, which can cause hemorrhagic necrosis of tumor tissue, including soluble TNF-α (sTNF-α) and membrane-associated TNF-α (mTNF-α) two kinds of form, is composed of three identical monomer sub-units of the compact trimer, with three to play a role in the form of polymers belonging to type Ⅱ membrane protein (ie, N terminal in the intracellular domain, C terminal to the extracellular domain) to maintain the integrity of the C terminal to the maintenance of the biological activity of TNF-α is essential. TNF-β by antigen or mitogen-stimulate