Type 1 regulatory T cells (Tr1) and Asthma Research_0.docVIP

 PAGE \* MERGEFORMAT 19 Type 1 regulatory T cells (Tr1) and Asthma Research [Abstract] type 1 regulatory T cells (type 1 regulatory T cells, Tr1 regulatory T cells are a kind, it can secrete immunosuppressive factors IL-10, or by contact inhibition mechanism, the effector T cells to produce a strong inhibition, in a variety of autoimmune diseases, including asthma play an important role. In this paper, the source of Tr1, biological characteristics, and the pathogenesis of asthma, especially in relation with the treatment of asthma do a review to explore new ideas for asthma treatment . [Keywords:] Tr1, asthma, treatment Bronchial asthma is a serious threat to global public health within a respiratory allergic disease in recent years, the incidence and mortality of asthma is rising, so the etiology of asthma pathogenesis has become a research hotspot. The etiology involves genetic, environment and the immune and other aspects, pathogenesis is not fully understood, including asthma Th1/Th2 balance theory is the most important immunological mechanisms [1]. The theory is that the incidence of asthma in vivo Th1/Th2 balance disorder. more found, Th1 cells as a pro-inflammatory cells, not only can not decrease Th2-induced airway hyperresponsiveness and inflammation, but lead to Th1-related inflammatory reaction in the maintenance of chronic airway inflammation of asthma terms of their IFN- secretion and Th2 There are synergistic effect of cytokines, the increase of asthma and allergic diseases, while Th2 cells in immune-mediated diseases the incidence of asthma has not increased [2]. Therefore, the simple theory does not explain Th1/Th2 cell balance the development of asthma in the entire process. With the Th1, Th2 cells other than T subsets (regulatory T cells, Tr discovery, people gradually realize that Tr in the important role of bronchial asthma. And Tr 1 in the regulation T-cells (Tr1 and asthma is cause for concern. Type of regulatory T cells 11 (Tr