Ulinastatin vital organs in critically ill patients with acute Protection Study.docVIP

 PAGE \* MERGEFORMAT 16 Ulinastatin vital organs in critically ill patients with acute Protection Study Ulinastatin (Ulinastatin, UTI) is an isolated and purified from human urine protease inhibitors, is a glycoprotein with a molecular weight of 67000D. By a 143 amino acid residues, its bioavailability was 100%, half-life of 40min, 5min peak. A large number of studies have shown that when the body is infected, fever, cancer, pregnancy, shock, surgery, given the stimulation of glucocorticoid hormones, activity increased in human urine UTI. Further study found that the memory in human plasma at high concentrations of protease inhibitors, while severe damage in the body, its being consumed, the concentration decreased significantly, but the random body recovery, and its concentration rise again. This indicates that UTI may have a resistance to external stimulation, to reduce the external damage factor on the body damage, the maintenance of environmental balance of the role of the human body. Subsequent research has fully confirmed this point, a large number of pharmacological studies and clinical efficacy studies have shown that: UTI can inhibit a variety of proteins, sugar and lipid hydrolase activity, inhibit the excessive release of inflammatory mediators, microcirculation and tissue perfusion and other important pharmacological effects, resulting in the body by external injury has protective effects. 1 UTI on the possible mechanism of protection of vital organs UTI through the following mechanisms perform their protection functions: ① UTI is a typical Kunitz-type protease inhibitor, has two active functional areas, each have a very wide spectrum of inhibitory activity and do not completely overlap, can be combined, such as trypsin, a-chymotrypsin and other serine proteases and granulocyte elastase (PMNE), as well as hyaluronidase, sulfhydryl enzyme, plasminogen, sugar solution of enzymes and lipid hydrolytic enzymes variety of enzymes, com