Ultra Performance Liquid Chromatography Tandem Mass Spectrometry milk and milk powder 6 polyether antibiotics residues.docVIP

 PAGE \* MERGEFORMAT 16 Ultra Performance Liquid Chromatography Tandem Mass Spectrometry milk and milk powder 6 polyether antibiotics residues Study: Haibo Luo Lili thin star Yuxiu Pang Guofang Cao Yanzhong [Abstract] established for the detection of milk and milk powder in La Shaluo avermectin, monensin, Nigeria streptozotocin, salinomycin, and salinomycin methyl bromide 6 Maduramicin polyether antibiotic residues ultra-performance liquid chromatography tandem mass spectrometry method. extracted with acetonitrile samples polyether antibiotics, extraction by HLB solid phase extraction cartridges, the use of ultra-high performance liquid chromatography to electrospray ion source in positive ion multiple reaction monitoring mode mass spectrometry .6 antibiotics in the 0.5 ~ 100.0 μg / L showed a linear range, correlation coefficient rgt; 0.99. in the blank sample added 6 polyether antibiotics recoveries were 74.0% ~ 98.5% between; precision (RSD) 4.8% ~ 17.2%. milk 6 polyether antibiotics detection limits were 0.2 μg / L; milk powder 6 polyether antibiotics detection limits were 1.6 μg / kg. [Keywords:] polyether antibiotics, residue analysis, ultra-performance liquid chromatography tandem mass spectrometry, milk, milk powder 1 Introduction Polyether antibiotics (polyether antibiotics), also known as ionophore antibiotics, is widely used in animal husbandry industry, efficient, broad-spectrum anticoccidial drug and growth promoter. Polyether antibiotics in toxicology is a highly toxic or drama toxic substances, with a strong cytotoxicity, a small safety range. excessive use of polyether antibiotics can cause drug residues in animal products, serious harm to human health. Canada, China, the European Union and the United States and many other countries or international organizations to develop a polyether antibiotics residues. products of animal origin countries polyether antibiotic residues requirements are lower than 1.0 mg / kg. monensin in milk b