XRCC1 genetic polymorphism and bladder cancer case-control study of the relationship between.docVIP

 PAGE \* MERGEFORMAT 27 XRCC1 genetic polymorphism and bladder cancer case-control study of the relationship between Author: Zhang Wei, Xiang Yong-Bing, CHENG Jia-Rong, SHAO Chang-Xia, FANG Ru-Rong, Yuan Jianmin, high Yutang Abstract [Objective] To investigate the human DNA repair gene XRCC1 Arg194Trp single-nucleotide polymorphisms and bladder cancer risk relationship. [Methods] PCR, RFLP analysis detected 242 cases of bladder cancer patients and 225 population-based controls XRCC1 gene polymorphism of 194 points. Application of non-conditional Logistic regression model, adjusting for confounding factors, the analysis of the genotype and the relationship between bladder cancer and whether there is interaction between the factors associated with smoking. [Results] bladder cancer cases group 194Trp/Trp mutation genotype frequency (11.2%) was significantly higher (4.0%). Adjusted for age, sex, smoking, high-risk occupational history, bladder infections, and body mass index and other factors, to carry 194Trp/Trp genotype bladder cancer risk is 3.64 times the individual 194Arg/Arg genotype (95% CI: 1.60 ~ 8.30). The genotype and smoking on the risk of increased incidence of bladder cancer was no significant interaction. In addition to the confounding effects of smoking, 194Trp/Trp genotype the risk of bladder cancer was 3.16 times that of the other genotypes (95% CI: 1.45 ~ 6.88). [Conclusion] XRCC1 gene mutation genotype 194Trp/Trp increased incidence of bladder cancer risk, no interaction with smoking. Keywords: Bladder cancer case-control study of smoking epidemiology of XRCC1 single nucleotide polymorphisms Abstract: [Purpose] To investigate the relationship between the codon 194 arganine to tryptophan substitution polymorphism of X, ray repair cross complementing group 1 (XRCC1) and bladder cancer risk in a population, based case, control study. [Methods] A polymerase chain reaction, based assay was used to detect Pvu Ⅱ restriction