Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca英文文献资料.docVIP

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Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca英文文献资料.doc

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Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca英文文献资料

Research Communication Mediators of Inflammation, 11, 351–357 (2002) I T has been shown that Bothrops jararaca venom Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca (BjV) induces a significant leukocyte accumulation, mainly neutrophils, at the local of tissue damage. Therefore, the role of the adhesion molecules inter- cellular adhesion molecule-1 (ICAM-1), LECAM-1, CD18, leukocyte function-associated antigen–1 (LFA- 1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) on the BjV-induced neutrophil accumula- tion and the correlation with release of LTB4, TXA2, Stella R. Zamuner and Catarina F. P. Teixeira CA tumor necrosis factor- , interleukin (IL)-1 and IL-6 a have been investigated. Anti-mouse LECAM-1, LFA-1, ICAM-1 and PECAM-1 monoclonal antibody injection resulted in a reduction of 42%, 80%, 66% and 67%, respectively, of neutrophil accumulation induced by BjV (250mg/kg, intraperitoneal) injection in male mice compared with isotype-matched control injec- ted animals. The anti-mouse CD18 monoclonal anti- body had no significant effect on venom-induced neutrophil accumulation. Concentrations of LTB4, Laboratory of Pharmacology, Butantan Institute, Av. Vital Brazil 1500, Sa?o Paulo, SP CEP 05504 –900, Brazil CA Corresponding Author: Fax: +55 11 3726 1505 E-mail: cteixeir@usp.br TXA2, IL-6 and TNF- were significant increased in the a peritoneal exudates of animals injected with venom, whereas no increment in IL-1 was detected. This results suggest that ICAM-1, LECAM-1, LFA-1 and PECAM-1, but not CD18, adhesion molecules are involved in the recruitment of neutrophils into the inflammatory site induced by BjV. This is the first in vivoevidence that snake venom is able to up-regulate the expression of adhesion molecules by both leuko- cytes and endothelial cells. This venom effect may be indirect, probably through the release of the inflam- matory mediators evidenced in the present st