还少胶囊抗抑郁作用的实验研究.pdfVIP

药学与临床研究 2008年 12 月 Pha rmaceutci a l and C linica l Research 200 8, 16 ( 6) * 王 钰, 杨双双, 夏 星, 孔令东** 南京大学生命科学院, 南京 210093 : 测定还少胶囊对抑郁小鼠行为学生化指标的影响, 证实还少胶囊具有 抑郁疗效: 开场实验测定还少胶囊对正常小鼠自主活动能力的影响建立小鼠悬尾强迫游泳模型, 测定还少胶囊对抑郁 小鼠行为学脑部单胺类神经递质肝脏丙二醛和超氧化物歧化酶含量的影响: 经过 7 天给药, 小鼠自主 活动能力无显著改变悬尾强迫游泳实验中动物不动时间均显著减少与正常组对比, 还少胶囊正常组大部 分生化指标改变不显著; 与模型组对比, 还少胶囊模型组能显著增加中枢五羟色胺 ( 5HT ) 和去甲肾上腺素 ( N E)含量, 减少肝脏丙二醛(M DA ) 和超氧化物歧化酶 ( SOD ) 含量, 且中低剂量时效果更好, 优于氟西汀 : 还少胶囊具有良好 抑郁作用, 对正常动物相关生化指标影响很小, 且无中枢神经兴奋作用 还少胶囊; 抑郁小鼠; 悬尾实验; 强迫游泳实验; 单胺类神经递质; 丙二醛; 超氧化物歧化酶 R285. 5 A 167 37806( 200 8) 0644604 * The antidep ressant effect of Huanshao Capus le ** WAN G Y u, YANG Shuangshuang, X IA X ng, KONG L ngdong School of Lif e Sciences, Nanj ing University, N anjing 210093, China Abstract O bjective: To conf rm the ant depressant effect of H uanshao C apsu le by study ng ts effects on depress on m ce behav or and b ochem stry param eters. M e thod: The effect of H uanshao C apsu le on m ce locom otor act v ty w ere evaluated by openf e ld test. T he m ce m odels were the ta l su spens on test and the forced sw mm ng test. T he effects o fH uanshao Cap sule on depress on m ce behav or, m onoam ne neurotransm tters n bra n, SOD and MDA n l ver w ere observed. Resu l:t A fter 7 daystreatm ent, the m ce locom otor act v ty had no s gn f cant change. T he mm ob l ty t m e n TST and FST decreased s gn f cantly. Com pared w th the control group, H uanshao C apsu le control groups had no s gn f cant e