儿童传染性单核细胞增多症合并肝功能损害.pdfVIP

44 West China Medical Journal Vol.27 No.8 Aug. 2012 2012 27 , , 华西医学 , （8） 论　著 传染性单核细胞增多症合并肝损害的临床特征 罗泽民，苏海涛，谢娜 【摘要】　目的　总结儿童传染性单核细胞增多症 (IM) 合并肝损害的临床特点及相关因素。 方法　对 2000 年 1 月－ 2012 年 1 月入院收治 48 例合并肝损害 IM 与 120 例无肝损害 IM 的患儿年龄、性别、主要症状和体征、系 统损害、实验室检查等资料进行回顾性分析。 结果　合并肝损害 IM 患儿血小板减少、异形淋巴细胞增加、丙氨酸 氨基转换酶和天门冬氨酸氨基转移酶等血清酶学异常、持续发热、中重度肝脾肿大，以及多系统损害发生率较高； 而咽峡炎、皮疹和浅表淋巴结肿大发生率较低；IM 合并肝损害与发病年龄、性别无明显相关（r=0.127 ，r=0.075 ， P ＜ 0.05 ）。 结论　IM 合并肝损害表现为持续发热、肝脾肿大、肝酶异常、血小板减少、异形淋巴细胞增加较常见。 及时作肝功能等辅助检查，及早发现和干预 IM 肝损害，有助于减少重症 IM 的发生。 【关键词】　小儿传染性单核细胞增多症；肝功能损害；并发症 【文献标识码】　A　　　 Clinical features of infectious mononucleosis with liver damage in children　LUO Ze-min, SU Hai-tao, XIE Na. Department of Pediatrics , Sichuan Provincial Hospital for Women and Children , Chengdu，Sichuan 610041, P.R.China Corresponding Author: LUO ze-min,E-mail:houp1991@163.com 【Abstract】 Objective The Clinical characteristics and related factors of infectious mononucleosis (IM) combined with liver damage are concluded. Methods 48cases of infectious mononucleosis with liver damage and 120 cases of infectious mononucleosis without liver damage received and cured from Jan, 2000 to Jan, 2012 were reviewed retrospectively. Such clinical data of the patients in each case was collected and analyzed as age, gender, main symptoms and signs, systematic damage, Laboratory characteristics ,etc. Results After comparison, the patients of IM with liver damage have thrombocytopenia, increasing number of variability lymphocytes, moderate to severe liver and spleen enlargement, high inciden