A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y-Linked Male Fertility Genes 英文参考文献.docVIP
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A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y-Linked Male Fertility Genes 英文参考文献
AYoungDrosophilaDuplicateGenePlaysEssentialRoles
inSpermatogenesisbyRegulatingSeveralY-LinkedMale
FertilityGenes
YunDing1,2.,LiZhao1,2.,ShuangYang1,YuJiang1,2,YuanChen1,2,RuopingZhao1,YueZhang1 ,Guojie
Zhang1,2,YangDong1,2,HaijingYu3,QiZhou1,2¤,WenWang1*
1State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China, 2Graduate University of
ChineseAcademyofSciences,Beijing,China,3LaboratoryforConservationandUtilizationofBio-ResourcesandHumanGeneticsCenterofYunnanUniversity,Kunming,
China
Abstract
Geneduplicationissupposedtobethemajorsourceforgeneticinnovations.However,howanewduplicategeneacquires
functions by integrating intoa pathwayandresults in adaptively importantphenotypes has remained largely unknown.
Here,weinvestigatedthebiologicalrolesandtheunderlyingmolecularmechanismoftheyoungkep1genefamilyinthe
Drosophila melanogaster species subgroup to understand the origin and evolution of new genes with new functions.
Sequence and expression analysis demonstrates that one of the new duplicates, nsr (novel spermatogenesis regulator),
exhibits positive selection signals and novel subcellular localization pattern. Targeted mutagenesis and whole-
transcriptome sequencing analysis provide evidence that nsr is required for male reproduction associated with sperm
individualization, coiling, and structural integrity of the sperm axoneme via regulation of several Y chromosome fertility
genes post-transcriptionally. The absence of nsr-like expression pattern and the presence of the corresponding cis-
regulatoryelementsoftheparentalgenekep1inthepre-duplicationspeciesDrosophilayakubaindicatethatkep1mightnot
beancestrallyrequiredformalefunctionsandthatnsrpossiblyhasexperiencedtheneofunctionalizationprocess,facilitated
bychangesoftrans-regulatoryrepertories.Thesefindingsnotonlypresentacomprehensivepictureabouttheevolutionof
a new duplicate gene but also show that recently originated duplicate genes can acquir
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