A “Spike-Based” Grammar Underlies Directional Modification in Network Connectivity Effect on Bursting Activity and Implications for Bio-Hybrids Systems 英文参考文献.docVIP
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A “Spike-Based” Grammar Underlies Directional Modification in Network Connectivity Effect on Bursting Activity and Implications for Bio-Hybrids Systems 英文参考文献
A‘‘Spike-Based’’GrammarUnderliesDirectional
ModificationinNetworkConnectivity:EffectonBursting
ActivityandImplicationsforBio-HybridsSystems
LetiziaZullo1*,MichelaChiappalone1,SergioMartinoia1,2,FabioBenfenati1,3
1DepartmentofNeuroscienceandBrainTechnologies,IstitutoItalianodiTecnologia,Genoa,Italy,2DepartmentofInformatics,Bioengineering,RoboticsandSystem
Engineering,UniversityofGenoa,Genoa,Italy,3DepartmentofExperimentalMedicine,UniversityofGenoa,Genoa,Italy
Abstract
Developedbiologicalsystemsareendowedwiththeabilityofinteractingwiththeenvironment;theysensetheexternal
stateandreacttoitbychangingtheirowninternalstate.Manyattemptshavebeenmadetobuild‘hybrids’withtheability
ofperceiving,modifyingandreactingtoexternalmodifications.Investigationoftherulesthatgovernnetworkchangesina
hybridsystemmayleadtofindingeffectivemethodsfor‘programming’theneuraltissuetowardadesiredtask.Herewe
show a new perspective in the use of cortical neuronal cultures from embryonic mouse as a working platform to study
targetedsynapticmodifications.Differentlyfromthecommontiming-basedmethodsappliedinbio-hybridsrobotics,here
weevaluatedtheimportanceofendogenousspiketimingintheinformationprocessing.Wecharacterizedtheinfluenceof
aspike-patternedstimulusindeterminingchangesinneuronalsynchronization(connectivitystrengthandprecision)ofthe
evokedspikingandburstingactivityinthenetwork.Weshowthattailoringthestimulationpatternuponaneuronalspike
timing induces the network to respond stronger and more precisely to the stimulation. Interestingly, the induced
modificationsareconveyedmoreconsistentlyinthebursttiming.Thisincreaseinstrengthandprecisionmaybeakeyin
the interaction of the network with the external world and may be used to induce directional changes in bio-hybrid
systems.
Citation:ZulloL,ChiappaloneM,MartinoiaS,BenfenatiF(2012)A‘‘Spike-Based’’GrammarUnderliesDirectionalModificationinNetworkConnectivity:Effecton
BurstingActivityandImplicationsforBio-HybridsSystems.PLoSONE7(11):e49299.doi:10.1371/jou
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