Active Dendrites Enhance Neuronal Dynamic Range 英文参考文献.docVIP

Active Dendrites Enhance Neuronal Dynamic Range 英文参考文献.doc

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Active Dendrites Enhance Neuronal Dynamic Range 英文参考文献

ActiveDendritesEnhanceNeuronalDynamicRange LeonardoL.Gollo1,2*,OsameKinouchi3,MauroCopelli1 1Laborato′rio de F?′sica Teo′rica e Computacional, Departamento de F?′sica, Universidade Federal de Pernambuco, Recife, Brazil, 2Instituto de F?′sica Interdisciplinar y SistemasComplejos,PalmadeMallorca,Spain,3FaculdadedeFilosofia,Cie?nciaseLetrasdeRibeira?o Preto,UniversidadedeSa?o Paulo,Ribeira?o Preto,Brazil Abstract Since the first experimental evidences of active conductances in dendrites, most neurons have been shown to exhibit dendriticexcitabilitythroughtheexpressionofavarietyofvoltage-gatedionchannels.However,despiteexperimentaland theoreticaleffortsundertakeninthepastdecades,theroleofthisexcitabilityforsomekindofdendriticcomputationhas remainedelusive.Hereweshowthat,owingtoverygeneralpropertiesofexcitablemedia,theaverageoutputofamodelof anactivedendritictreeisahighlynon-linearfunctionofitsafferentrate,attainingextremelylargedynamicranges(above 50dB).Moreover,themodelyieldsdouble-sigmoidresponsefunctionsasexperimentallyobservedinretinalganglioncells. Weclaimthatenhancementofdynamicrangeistheprimaryfunctionalroleofactivedendriticconductances.Wepredict thatneuronswithlargerdendritictreesshouldhavelargerdynamicrangeandthatblockingofactiveconductancesshould leadtoadecreaseindynamicrange. Citation: Gollo LL, Kinouchi O, Copelli M (2009) Active Dendrites Enhance Neuronal Dynamic Range. PLoS Comput Biol 5(6): e1000402. doi:10.1371/ journal.pcbi.1000402 Editor:LyleJ.Graham,Universite′ ParisDescartes,CentreNationaldelaRechercheScientifique,France ReceivedOctober6,2008;AcceptedMay4,2009;PublishedJune12,2009 Copyright: ? 2009 Gollo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:TheauthorsacknowledgefinancialsupportfromBrazilianagenciesConselhoNacionaldeDesenvolvimentoCient?′ficoe

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