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Adaptive Evolution of the FADS Gene Cluster within Africa 英文参考文献
AdaptiveEvolutionoftheFADSGeneClusterwithin
Africa
RasikaA.Mathias1,2*,WenqingFu3,JoshuaM.Akey3,HannahC.Ainsworth4,5,DaraG.Torgerson6,
IngoRuczinski7,SusanSergeant4,5,KathleenC.Barnes2,FloydH.Chilton5,8
1DivisionofGeneralInternalMedicine,DepartmentofMedicine,TheJohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica,2DivisionofAllergyand
ClinicalImmunology,DepartmentofMedicine,TheJohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica,3DepartmentofGenomeSciences,Schoolof
Medicine,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,4DepartmentofBiochemistry,WakeForestUniversityHealthSciences,Winston-Salem,
North Carolina, United States of America, 5Wake Forest Center for Botanical Lipids and Inflammatory Disease Prevention, Wake Forest University Health Sciences,
Winston-Salem, North Carolina, United States of America, 6Department of Medicine, University of California San Francisco, San Francisco, California, United States of
America,7DepartmentofBiostatistics, BloombergSchoolofPublicHealth,JohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica, 8Department of
Physiology/Pharmacology,WakeForestUniversityHealthSciences,Winston-Salem,NorthCarolina,UnitedStatesofAmerica
Abstract
Long chain polyunsaturated fatty acids (LC-PUFAs) are essential for brain structure, development, and function, and
adequatedietaryquantitiesofLC-PUFAsarethoughttohavebeennecessaryforbothbrainexpansionandtheincreasein
braincomplexityobservedduringmodernhumanevolution.PreviousstudiesconductedinlargelyEuropeanpopulations
suggestthathumanshavelimitedcapacitytosynthesizebrainLC-PUFAssuchasdocosahexaenoicacid(DHA)fromplant-
based medium chain (MC)PUFAs due tolimited desaturase activity. Population-based differencesin LC-PUFA levelsand
their product-to-substrate ratios can, in part, be explained by polymorphisms in the fatty acid desaturase (FADS ) gene
cluster, which have been associated with increased conversion of MC-PUFAs to LC-PUFAs. Here, we show e
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