Adenomatous Polyposis Coli Regulates Axon Arborization and Cytoskeleton Organization via Its N-Terminus 英文参考文献.docVIP

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Adenomatous Polyposis Coli Regulates Axon Arborization and Cytoskeleton Organization via Its N-Terminus 英文参考文献.doc

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Adenomatous Polyposis Coli Regulates Axon Arborization and Cytoskeleton Organization via Its N-Terminus 英文参考文献

AdenomatousPolyposisColiRegulatesAxon ArborizationandCytoskeletonOrganizationviaIts N-Terminus YoujunChen1,XuTian2,Woo-YangKim3,WilliamD.Snider1* 1Department of Celland Molecular Physiology and Neuroscience Center, School ofMedicine, University of North Carolina atChapel Hill, Chapel Hill, North Carolina, UnitedStatesofAmerica,2HefeiNationalLaboratoryforPhysicalSciencesatMicroscaleandSchoolofLifeSciences,UniversityofScienceandTechnologyofChina,Hefei, Anhui Province, People’s Republic of China, 3Department of Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska,UnitedStatesofAmerica Abstract Conditional deletion of APC leads to marked disruption of cortical development and to excessive axonal branching of corticalneurons.However,littleisknownaboutthecellbiologicalbasisofthisneuronalmorphologicalregulation.Herewe show that APC deficient cortical neuronal growth cones exhibit marked disruption of both microtubule and actin cytoskeleton.FunctionalanalysisofthedifferentAPCdomainsrevealedthataxonalbranchesdonotresultfromstabilized b-catenin,andthattheC-terminusofAPCcontainingmicrotubuleregulatorydomainsonlypartiallyrescuesthebranching phenotype. Surprisingly, the N-terminus of APC containing the oligomerization domain and the armadillo repeats completely rescues the branching and cytoskeletal abnormalities. Our data indicate that APC is required for appropriate axonmorphologicaldevelopmentandthattheN-terminusofAPCisimportantforregulationoftheneuronalcytoskeleton. Citation: Chen Y, Tian X, Kim W-Y, Snider WD (2011) Adenomatous Polyposis Coli Regulates Axon Arborization and Cytoskeleton Organization via Its N-Terminus.PLoSONE6(9):e24335.doi:10.1371/journal.pone.0024335 Editor:MichaelA.Fox,VirginiaCommonwealthUniversityMedicalCenter,UnitedStatesofAmerica ReceivedJune15,2011;AcceptedAugust4,2011;PublishedSeptember6,2011 Copyright: ? 2011 Chen et al. This is an open-access article distributed under the terms of the Creati