Adenotonsillectomy and Neurocognitive Deficits in Children with Sleep Disordered Breathing 英文参考文献.docVIP

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Adenotonsillectomy and Neurocognitive Deficits in Children with Sleep Disordered Breathing 英文参考文献.doc

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Adenotonsillectomy and Neurocognitive Deficits in Children with Sleep Disordered Breathing 英文参考文献

AdenotonsillectomyandNeurocognitiveDeficitsin ChildrenwithSleepDisorderedBreathing MarkJ.Kohler1,2*,KurtLushington3,CameronJ.vandenHeuvel1,JamesMartin1,4,YvonnePamula4, DeclanKennedy1,4 1Children’sResearchCentre,UniversityofAdelaide,NorthAdelaide,Australia,2CentreforSleepResearch,UniversityofSouthAustralia,Adelaide,Australia,3Schoolof Psychology,UniversityofSouthAustralia,Adelaide,Australia,4DepartmentofRespiratoryandSleepMedicine,Women’sandChildren’sHospital,NorthAdelaide,Australia Abstract Background:SleepDisorderedBreathing(SDB)isacommonchildhooddisorderthatencompassesarangeofsleep-related upperairwayobstruction.ChildrenwithSDBdemonstratesignificantneurocognitivedeficits.Adenotonsillectomyisthefirst line of treatment for SDB and whilst this improves respiratory disturbance, it remains to be established whether neurocognitivegainsalsoresult. Methods:Atotalof44healthysnoringchildrenaged3–12yearsawaitingadenotonsillectomy(SDBgroup),and48ageand gender matched non-snoring controls from the general community, completed the study. All children underwent polysomnographyandneurocognitiveassessmentatbaselineandaftera6-monthfollow-up(aftersurgeryinthesnoring group).Ourprimaryaimwastodeterminewhetherneurocognitivedeficitsinsnoringchildrenweresignificantlyimproved followingadenotonsillectomy. Results:WiderangingneurocognitivedeficitswerefoundatbaselineinSDBchildrencomparedtocontrols,mostnotablya 10pointIQdifference(P,.001)andsimilardeficitsinlanguageandexecutivefunction.Whilstadenotonsillectomyimproved respiratory parameters and snoring frequency at 6 months post surgery, neurocognitive performance did not improve relativetocontrols. Conclusion: Adenotonsillectomy successfully treated the respiratory effects of SDB in children. However, neurocognitive deficitsdidnotimprove6-monthspost-operatively. Citation:KohlerMJ,LushingtonK,vandenHeuvelCJ,MartinJ,PamulaY,etal.(2009)AdenotonsillectomyandNeurocognitiveDeficitsinChildrenwithSleep DisorderedBreathing.PLoSONE4(10):e7343.doi:1