Adenovirus-36 Is Associated with Obesity in Children and Adults in Sweden as Determined by Rapid ELISA 英文参考文献.docVIP
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Adenovirus-36 Is Associated with Obesity in Children and Adults in Sweden as Determined by Rapid ELISA 英文参考文献
Adenovirus-36IsAssociatedwithObesityinChildrenand
AdultsinSwedenasDeterminedbyRapidELISA
MalinAlmgren1,2,3,RichardAtkinson4*,JiaHe4,AgnetaHilding1,EmiliaHagman5,AlicjaWolk6,
AndersThorell7,ClaudeMarcus5,ErikNa¨slund8,Claes-Go¨ranOstenson¨ 1,MartinSchalling1,2,
CatharinaLavebratt1,2
*
1DepartmentofMolecularMedicineandSurgery,KarolinskaInstitutet,Stockholm,Sweden,2CenterforMolecularMedicine,KarolinskaUniversityHospital,Stockholm,
Sweden,3DepartmentofClinicalNeuroscience,KarolinskaInstitutet,Stockholm,Sweden,4ObetechObesityResearchCenterandVirginiaCommonwealthUniversity,
Richmond, Virginia, United States of America, 5Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm,
Sweden, 6Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 7Department of Clinical Sciences,
DanderydHospital,KarolinskaInstitutetandDepartmentofSurgery,ErstaHospital,Stockholm,Sweden,8DivisionofSurgery,DepartmentofClinicalSciences,Danderyd
Hospital,KarolinskaInstitutet,Stockholm,Sweden
Abstract
Background:Experimentalandnaturalhumanadenovirus-36(Adv36)infectionofmultipleanimalspeciesresultsinobesity
throughincreasingadipogenesisandlipidaccumulationinadipocytes.PresenceofAdv36antibodiesdetectedbyserum
neutralizationassayhaspreviouslybeenassociatedwithobesityinchildrenandadultslivingintheUSA,SouthKoreaand
Italy, whereas no association with adult obesity was detected in Belgium/the Netherlands nor among USA military
personnel.Adv36infectionhasalsobeenshowntoreducebloodlipidlevels,increaseglucoseuptakebyadiposetissueand
skeletalmusclebiopsies,andtoassociatewithimprovedglycemiccontrolinnon-diabeticindividuals.
PrincipalFindings:UsinganovelELISA,1946clinicallywell-characterizedindividualsincluding424childrenand1522non-
diabetic adults, and 89 anonymous blood donors, residing in central Sweden representing the population in Stockholm
area, were studied for the pr
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