Adequate Levels of Adherence with Controller Medication Is Associated with Increased Use of Rescue Medication in Asthmatic Children 英文参考文献.docVIP
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Adequate Levels of Adherence with Controller Medication Is Associated with Increased Use of Rescue Medication in Asthmatic Children 英文参考文献
AdequateLevelsofAdherencewithController
MedicationIsAssociatedwithIncreasedUseofRescue
MedicationinAsthmaticChildren
HajerElkout1,PeterJ.Helms1,ColinR.Simpson2,3,JamesS.McLay1*
1Department of Child Health, Division of Applied Health Sciences School of Medicine, University of Aberdeen, Aberdeen, United Kingdom, 2Department of General
PracticeandPrimaryCare,DivisionofAppliedHealthSciencesSchoolofMedicine,UniversityofAberdeen,Aberdeen,UnitedKingdom,3CentreforPopulationHealth
Sciences,ForesterhillHealthCentre,UniversityofEdinburgh,Edinburgh,UnitedKingdom
Abstract
Background: The role of asthma controller medication adherence and the level of asthma control in children is poorly
defined.
Aims: To assess the association between asthma controller medication adherence and asthma control in children using
routinelyacquiredprescribingdata.
Methods: A retrospective observational study of children aged 0–18 years prescribed inhaled corticosteroids only (ICS),
leukotriene receptors antagonists (LTRA), orlong-acting b2 agonists (LABA) andICS prescribed as separateor combined
inhalers, between 01/09/2001 and 31/08/2006, registered with primary care practices contributing to the Practice Team
Informationdatabase.Themedicationpossessionratio(MPR)wascalculatedandassociationswithasthmacontrolexplored.
Poorasthmacontrolwasdefinedastheissueofprescriptionsfor$1courseoforalcorticosteroids(OCS)and/or$ 6short-
actingb2agonists(SABA)canistersannually.
Results:Atotalof3172childrenprescribedasthmacontrollermedicationwereidentified.Ofthese,15–39%(dependingon
controller medication) demonstrated adequate MPR. Adequate MPR was associated with male gender, good socio-
economic status, and oral LTRA therapy. Adequate MPR was more likely to be associated with increased use of rescue
medication. However logistic regression only identified a significant relationship for ICS only (odds ratio [OR], 1.89; 95%
confidenceinterval[CI],1.35–2.48;p,0.001),LTRA(OR,2.11;95%CI,1.27–3.48;p=0.004)andLABA/ICS(OR,2
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