Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo 英文参考文献.docVIP
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Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo 英文参考文献
AdultStromalCellsDerivedfromHumanAdiposeTissue
ProvokePancreaticCancerCellDeathbothInVitroand
InVivo
BeatriceCousin1,2*,EmmanuelRavet1,2,SandrinePoglio1,2,FabienneDeToni1,2,Me′lanieBertuzzi1,2
,
HubertLulka3,IsmahaneTouil1,2,MireilleAndre′1,2,Jean-LouisGrolleau4,Jean-MariePe′ron3 ,Jean-Pierre
Chavoin4,PhilippeBourin5,LucPe′nicaud1,2,LouisCasteilla1,2,LouisBuscail3,PierreCordelier3
1Universite′deToulouse,UPS,UMR5241Me′tabolisme,Plasticite′etMitochondrie,BP84225,Toulouse,France,2CNRS,UMR5241Me′tabolisme,Plasticite′etMitochondrie,
BP84225,Toulouse,France,3InstitutNationaldelaSante′etdelaRechercheMe′dicaleU858,I2MRandIFRBMT-150,BP84225,Toulouse,France,4DepartmentofPlastic
Surgery,CentreHospitalierUniversitaireRangueil,BP84225,Toulouse,France,5EFS-PM,Laboratoiredethe′rapiecellulaire,Toulouse,France
Abstract
Background: Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their
microenvironment.Disruptingthishomeostasiscaninduceaberrantcellproliferation,adhesion,functionandmigrationthat
might promote malignant behavior. Indeed, aberrant stromal-epithelial interactions contribute to pancreatic ductal
adenocarcinoma (PDAC) spread and metastasis, and this raises the possibility that novel stroma-targeted therapies
representadditionalapproachesforcombatingthismalignantdisease.Theaimofthepresentstudywastodeterminethe
effectofhumanstromalcellsderivedfromadiposetissue(ADSC)onpancreatictumorcellproliferation.
PrincipalFindings:Co-culturingpancreatictumorcellswithADSCandADSC-conditionedmediumsampledfromdifferent
donors inhibited cancer cell viability and proliferation. ADSC-mediated inhibitory effect was further extended to other
epithelialcancer-derivedcelllines(liver,colon,prostate).ADSCconditionedmediuminducedcancercellnecrosisfollowing
G1-phasearrest,withoutevidenceofapoptosis.Invivo,asingleintra-tumoralinjectionofADSCinamodelofpancreatic
adenocarcinomainducedastrongandlong-lastinginhibitionoftumorgrowth.
Conclusion:Thesedataindicateth
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