Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese 英文参考文献.docVIP

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Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese 英文参考文献.doc

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Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese 英文参考文献

AdultType3AdenylylCyclase–DeficientMiceAreObese ZhenshanWang,VickyLi,GuyC.K.Chan,TronghaPhan,AaronS.Nudelman,ZhenguiXia,DanielR. Storm* DepartmentofPharmacology,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica Abstract Background:ArecentstudyofobesityinSwedishmenfoundthatpolymorphismsinthetype3adenylylcyclase(AC3)are associated with obesity, suggesting the interesting possibility that AC3may play arole in weight control. Therefore, we examinedtheweightofAC3miceoveranextendedperiodoftime. Methodology/PrincipalFindings:WediscoveredthatAC32/2micebecomeobeseastheyage.AdultmaleAC32/2mice areabout40%heavierthanwildtypemalemicewhilefemaleAC32/2are70%heavier.TheadditionalweightofAC32/2 miceisduetoincreasedfatmassandlargeradipocytes.Beforetheonsetofobesity,youngAC32/2miceexhibitreduced physicalactivity,increasedfoodconsumption,andleptininsensitivity.Surprisingly,theobesityofAC32/2miceisnotdueto alossofAC3fromwhiteadiposeandadecreaseinlipolysis. Conclusions/Significance:WeconcludethatmicelackingAC3exhibitobesitythatisapparentlycausedbylowlocomotor activity,hyperphagia,andleptininsensitivity.ThepresenceofAC3inprimaryciliaofneuronsofthehypothalamussuggests thatcAMPsignalsgeneratedbyAC3inthehypothalamusmayplayacriticalroleinregulationofbodyweight. Citation:WangZ,LiV,ChanGCK,PhanT,NudelmanAS,etal.(2009)AdultType3AdenylylCyclase–DeficientMiceAreObese.PLoSONE4(9):e6979.doi:10.1371/ journal.pone.0006979 Editor:JoeZ.Tsien,MedicalCollegeofGeorgia,UnitedStatesofAmerica ReceivedJuly21,2009;AcceptedAugust13,2009;PublishedSeptember11,2009 Copyright: ? 2009 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was supported by National Institutes of Health grant #DC04158. The funders had no role in study design, data collection and analysis, decisiontopublish,orpreparationofthem