Adverse Events in a Cohort of HIV Infected Pregnant and Non-Pregnant Women Treated with Nevirapine versus Non-Nevirapine Antiretroviral Medication 英文参考文献.docVIP

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Adverse Events in a Cohort of HIV Infected Pregnant and Non-Pregnant Women Treated with Nevirapine versus Non-Nevirapine Antiretroviral Medication 英文参考文献.doc

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Adverse Events in a Cohort of HIV Infected Pregnant and Non-Pregnant Women Treated with Nevirapine versus Non-Nevirapine Antiretroviral Medication 英文参考文献

AdverseEventsinaCohortofHIVInfectedPregnantand Non-PregnantWomenTreatedwithNevirapineversus Non-NevirapineAntiretroviralMedication ErikaAaron1*,Mirjam-ColetteKempf2,ShannonCriniti1,EllenTedaldi3,EdGracely4,AmyWarriner5 ,Ritu Kumar6,LauraH.Bachmann7,8 1DivisionofInfectiousDiseasesandHIVMedicine,DepartmentofMedicine,DrexelUniversityCollegeofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica, 2Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 3Temple University School of Medicine, Philadelphia,Pennsylvania,UnitedStatesofAmerica,4DepartmentofFamily,Community,andPreventiveMedicine,DrexelUniversityCollegeofMedicine,Philadelphia, Pennsylvania,UnitedStatesofAmerica,5DepartmentofMedicine,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStatesofAmerica,6Department of Internal Medicine, Mercer University, Macon, Georgia, United States of America, 7WG Hefner Medical Center, Salisbury, North Carolina, United States of America, 8WakeForestUniversityHealthSciences,Winston-Salem,NorthCarolina,UnitedStatesofAmerica Abstract Background:Predictorsofadverseevents(AE)associatedwithnevirapineuseareneededtobetterunderstandreportsof severerashorliverenzymeelevation(LEE)inHIV+women. Methodology: AE rates following ART initiation were retrospectively assessed in a multi-site cohort of 612 women. PredictorsofonsetofrashorLEEweredeterminedusingunivariateandmultivariateanalyses. Principal Findings: Of 612 subjects, 152 (24.8%) initiated NVP-based regimens with 86 (56.6%) pregnant; 460 (75.2%) initiatednon-NVPregimenswith67(14.6%)pregnant. LEE: No significant difference was found between regimens in the development of new grade $2 LEE (p=0.885). MultivariatelogisticregressiondemonstratedanincreasedlikelihoodofLEEwithHCVco-infection(OR2.502,95%CI:1.04to 6,p=0.040);pregnancy,NVP-basedregimen,andbaselineCD4.250cells/mm3werenotassociatedwiththistoxicity. Rash:NVPinitiationwasassociatedwithrashaftercontrollingforCD4andpregn