Aerosolized Human Extracellular Superoxide Dismutase Prevents Hyperoxia-Induced Lung Injury 英文参考文献.docVIP
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Aerosolized Human Extracellular Superoxide Dismutase Prevents Hyperoxia-Induced Lung Injury 英文参考文献
AerosolizedHumanExtracellularSuperoxideDismutase
PreventsHyperoxia-InducedLungInjury
Chih-ChingYen1,2,6.,Yi-WenLai1.,Hsiao-LingChen3,Cheng-WeiLai1,Chien-YuLin1,WeiChen1,4,
Yu-PingKuan1,Wu-HueiHsu2,7,Chuan-MuChen1,5
*
1Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, 2Department of Internal Medicine, China
MedicalUniversityHospital,Taichung,Taiwan,3DepartmentofBioresources,Da-YehUniversity,Changhwa,Taiwan,4DepartmentofInternalMedicine,Chia-YiChristian
Hospital,Chia-Yi,Taiwan,5SchoolofChineseMedicine,ChinaMedicalUniversity,Taichung,Taiwan,6CollegeofHealthCare,ChinaMedicalUniversity,Taichung,Taiwan,
7CollegeofMedicine,ChinaMedicalUniversity,Taichung,Taiwan
Abstract
An important issue in critical care medicine is the identification of ways to protect the lungs from oxygen toxicity and
reduce systemic oxidative stress in conditions requiring mechanical ventilation and high levels of oxygen. One way to
preventoxygentoxicityistoaugmentantioxidantenzymeactivityintherespiratorysystem.Thecurrentstudyinvestigated
the ability of aerosolized extracellular superoxide dismutase (EC-SOD) to protect the lungs from hyperoxic injury.
RecombinanthumanEC-SOD(rhEC-SOD)wasproducedfromasyntheticcassetteconstructedinthemethylotrophicyeast
Pichiapastoris.FemaleCD-1micewereexposedinhyperoxia(FiO2.95%)toinducelunginjury.Thetherapeuticeffectsof
EC-SODandcopper-zincSOD(CuZn-SOD)viaanaerosoldeliverysystemforlunginjuryandsystemicoxidativestressat24,
48, 72 and 96h of hyperoxia were measured by bronchoalveolar lavage, wet/dry ratio, lung histology, and 8-oxo-29-
deoxyguanosine(8-oxo-dG)inlungandlivertissues.Afterexposuretohyperoxia,thewet/dryweightratioremainedstable
beforeday2butincreasedsignificantlyafterday3.Thelevelsofoxidativebiomarker8-oxo-dGinthelungandliverwere
significantlydecreasedonday2(P,0.01)butthemarkerintheliverincreasedabruptlyafterday3ofhyperoxiawhenthe
mortalityincreased.TreatmentwithaerosolizedrhEC-SODincreas
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