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Age and Diet Affect Gene Expression Profiles in Canine Liver Tissue 英文参考文献
AgeandDietAffectGeneExpressionProfilesinCanine
LiverTissue
DongYongKil1,BrittanyM.VesterBoler1,CarolynJ.Apanavicius1,LawrenceB.Schook1,2,KellyS.
Swanson1,2,3
*
1DepartmentofAnimalSciences,UniversityofIllinois,Urbana,Illinois,UnitedStatesofAmerica,2DivisionofNutritionalSciences,UniversityofIllinois,Urbana,Illinois,
UnitedStatesofAmerica,3DepartmentofVeterinaryClinicalMedicine,UniversityofIllinois,Urbana,Illinois,UnitedStatesofAmerica
Abstract
Background:Theliverplaysacentralroleinnutrientandxenobioticmetabolism,butitsfunctionalitydeclineswithage.
Senior dogs suffer from many of the chronic hepatic diseases as elderly humans, with age-related alterations in liver
functioninfluencedbydiet.However,alarge-scalemolecularanalysisofthelivertissueasaffectedbyageanddiethasnot
beenreportedindogs.
Methodology/PrincipalFindings:Livertissuesampleswerecollectedfromsixsenior(12-yearold)andsixyoungadult(1-
yearold)femalebeaglesfedananimalprotein-baseddiet(APB)oraplantprotein-baseddiet(PPB)for12months.TotalRNA
inthelivertissuewasextractedandhybridizedtoAffymetrixGeneChipHCanineGenomeArrays.Usinga2.0-foldcutoffand
falsediscoveryrate,0.10,ourresultsindicatedthatexpressionof234geneswasalteredbyage,while137geneswere
differentially expressed by diet. Based on functional classification, genes affected by age and/or diet were involved in
cellulardevelopment,nutrientmetabolism,andsignaltransduction.Ingeneral,geneexpressionsuggestedthatseniordogs
had an increased risk of the progression of liver disease and dysfunction, as observed in aged humans and rodents. In
particularforagedliver,genesrelatedtoinflammation,oxidativestress,andglycolysiswereup-regulated,whereasgenes
relatedtoregeneration,xenobioticmetabolism,andcholesteroltraffickingweredown-regulated.Diet-associatedchanges
ingeneexpressionweremorecommoninyoungadultdogs(33genes)ascomparedtoseniordogs(3genes).
Conclusion:Ourresultsprovidemolecularinsightpertainingtotheagedcanineliveranditspredispositiontodiseaseand
abnormalities.Therefore
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