Age-Specific Sex-Related Differences in Infections A Statistical Analysis of National Surveillance Data in Japan 英文参考文献.docVIP
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Age-Specific Sex-Related Differences in Infections A Statistical Analysis of National Surveillance Data in Japan 英文参考文献
Age-SpecificSex-RelatedDifferencesinInfections:A
StatisticalAnalysisofNationalSurveillanceDatainJapan
NobuokiEshima1,OsamuTokumaru2*,ShoheiHara3,KiraBacal4,SeigoKorematsu5,ShigeruKarukaya6,
KiyoUruma1,NobuhikoOkabe7,ToyojiroMatsuishi6
1DepartmentofBiostatistics,FacultyofMedicine,OitaUniversity,Yufu,Oita,Japan,2DepartmentofNeurophysiology,FacultyofMedicine,OitaUniversity,Yufu,Oita,
Japan,3EditorialBureau,TheYomiuriShimbunOsaka(newspaper),Osaka,Japan,4MedicalProgrammeDirectorate,FacultyofMedicalandHealthSciences,Universityof
Auckland,Auckland,NewZealand,5DepartmentofPediatricsandChildNeurology,FacultyofMedicine,OitaUniversity,Yufu,Oita,Japan,6DepartmentofPediatricsand
ChildHealth,KurumeUniversitySchoolofMedicine,Kurume,Fukuoka,Japan,7InfectiousDiseaseSurveillanceCenter,NationalInstituteofInfectiousDiseases,Shinjuku,
Tokyo,Japan
Abstract
Background:Topreventandcontrolinfectiousdiseases,itisimportanttounderstandhowsexandageinfluencemorbidity
rates,butconsistentcleardescriptionsofdifferencesinthereportedincidenceofinfectiousdiseasesintermsofsexandage
aresparse.
MethodsandFindings:DatafromtheJapanesesurveillancesystemforinfectiousdiseasesfrom2000to2009wereusedin
theanalysisofsevenviralandfourbacterialinfectiousdiseaseswithrelativelylargeimpactontheJapanesecommunity.The
male-to-femalemorbidity(MFM)ratiosindifferentagegroupswereestimatedtocompareincidenceratesofsymptomatic
reported infection between the sexes at different ages. MFM ratios were .1 for five viral infections out of seven in
childhood, i.e. male children were more frequently reported as infected than females with pharyngoconjunctival fever,
herpangina, hand-foot-and-mouth disease, mumps, and varicella. More males were also reported to be infected with
erythemainfectiosumandexanthemasubitum,butonlyinchildren1yearofage.Bycontrast,inadulthoodtheMFMratios
decreasedto,1foralloftheviralinfectionsaboveexceptvaricella,i.e.adultwomenweremorefrequentlyreportedtobe
infectedthanmen.Sex-andage-relateddifferencesinreported
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