Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection 英文参考文献.docVIP
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Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection 英文参考文献
Age-RelatedPatternsinHumanMyeloidDendriticCell
PopulationsinPeopleExposedtoSchistosoma
haematobiumInfection
NormanNausch1*,DelphineLouis2,3,OlivierLantz2,3,4,IsabellePeguillet2,3,Franc?ois Trottein5,
IsobelY.D.Chen1,LauraJ.Appleby1,ClaireD.Bourke1¤a,NicholasMidzi6¤b,TakafiraMduluza7,
FranciscaMutapi1
1Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, University of
Edinburgh, Edinburgh, United Kingdom, 2Institut Curie, De′partement deBiologie des Tumeurs, Paris, France, 3Centre d’Investigation Clinique IGR-Curie,CIC-BT-507,
Paris,France,4Unite′Inserm932,InstitutCurie,Paris,France,5CenterforInfectionandImmunityofLille,InsermU1019,CNRSUMR8204,Universite′LilleNorddeFrance,
InstitutPasteurdeLille,Lille,France,6NationalInstituteofHealthResearch,Causeway,Harare,Zimbabwe,7DepartmentofBiochemistry,UniversityofZimbabwe,Mount
Pleasant,Harare,Zimbabwe
Abstract
Background:UrogenitalschistosomiasisiscausedbythehelminthparasiteSchistosomahaematobium.Inhightransmission
areas,childrenacquireschistosomeinfectionearlyinlifewithinfectionlevelspeakinginearlychildhoodandsubsequently
declining in late childhood. This age-related infection profile is thought to result from the gradual development of
protective acquiredimmunity. Age-related differences in schistosome-specific humoral andcellular responses havebeen
reportedfromseveralfieldstudies.Howevertherehasnotyetbeenasystematicstudyoftheage-relatedchangesinhuman
dendriticcells,thedriversofTcellpolarisation.
Methods:Peripheralbloodmononuclearcellswereobtainedfromacohortof61Zimbabweanaged5–45yearswithaS.
haematobium prevalence of 47.5%. Two subsets of dendritic cells, myeloid and plasmacytoid dentritic cells (mDCs and
pDCs),wereanalyzedbyflowcytometry.
Findings:Inthispopulation,schistosomeinfectionlevelspeakedintheyoungestagegroup(5–9years),anddeclinedinlate
childhoodandadulthood(10+years).TheproportionsofbothmDCsandpDCsvariedwithage.H
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