Aging and Estrogen Status A Possible Endothelium-Dependent Vascular Coupling Mechanism in Bone Remodeling 英文参考文献.docVIP
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Aging and Estrogen Status A Possible Endothelium-Dependent Vascular Coupling Mechanism in Bone Remodeling 英文参考文献
AgingandEstrogenStatus:APossibleEndothelium-
DependentVascularCouplingMechanisminBone
Remodeling
RhondaD.Prisby1,JamesM.Dominguez II2,JudyMuller-Delp3,MatthewR.Allen4,MichaelD.Delp2*
1Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, United States of America, 2Department of Applied Physiology and
KinesiologyandtheCenterforExerciseScience,UniversityofFlorida,Gainesville,Florida,UnitedStatesofAmerica,3DepartmentofPhysiologyandFunctionalGenomics,
University of Florida, Gainesville, Florida, United States of America, 4Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis,
Indiana,UnitedStatesofAmerica
Abstract
Bonelosswithagingandmenopausemaybelinkedtovascularendothelialdysfunction.Thepurposeofthestudywasto
determinewhetherputativemodificationsinendothelium-dependentvasodilationoftheprincipalnutrientartery(PNA)of
thefemurareassociatedwithchangesintrabecularbonevolume(BV/TV)withalteredestrogenstatusinyoung(6mon)and
old (24 mon) female Fischer-344 rats. Animals were divided into 6 groups: 1) young intact, 2) old intact, 3) young
ovariectomized (OVX), 4) old OVX, 5) young OVX plus estrogen replacement (OVX+E2), and 6) old OVX+E2. PNA
endothelium-dependent vasodilation was assessed in vitro using acetylcholine. Trabecular bone volume of the distal
femoral metaphysis was determined by microCT. In young rats, vasodilation was diminished by OVX and restored with
estrogenreplacement(intact,8267;OVX,6169;OVX+E2,9064%),whichcorrespondedwithsimilarmodificationsinBV/TV
(intact,28.761.6;OVX,16.360.9;OVX+E2,25.761.4%).Inoldanimals,vasodilationwasunaffectedbyOVXbutenhanced
withestrogenreplacement(intact,5568;OVX,5967;OVX+E2,9264%).Likewise,modificationsinBV/TVfollowedthesame
pattern(intact,33.161.6;OVX,34.463.7;OVX+E2,42.462.1%).Furthermore,inoldanimalswithlowendogenousestrogen
2
(i.e., intact and old OVX), vasodilation was correlated with BV/TV (R =0.630; P,0.001). These data demonstrate parallel
effe
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