Augmentation Cystoplasty and Extracellular Matrix Scaffolds An Ex Vivo Comparative Study with Autogenous Detubularised Ileum 英文参考文献.docVIP
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Augmentation Cystoplasty and Extracellular Matrix Scaffolds An Ex Vivo Comparative Study with Autogenous Detubularised Ileum 英文参考文献
AugmentationCystoplastyandExtracellularMatrix
Scaffolds:AnExVivoComparativeStudywith
AutogenousDetubularisedIleum
NiallF.Davis1,2,RoryMooney2,AnthonyCallanan2,HughD.Flood1,TimM.McGloughlin2*
1DepartmentofUrology,Mid-WesternRegionalHospital,Limerick,Ireland,2CentreforAppliedBiomedicalEngineeringResearchandMSSI,UniversityofLimerick,Ireland
Abstract
Background:Augmentationcystoplasty(AC)withautogenousileumremainsthecurrentgoldstandardsurgicaltreatment
formanypatientswithend-stagebladderdisease.However,thepresenceofmucus-secretingepitheliumwithinthebladder
isassociatedwithdebilitatinglong-termcomplications.Currently,decellularisedbiologicalmaterialsderivedfromporcine
extracellularmatrix(ECM)areunderinvestigationaspotentialaugmentationscaffolds.Importantbiomechanicallimitations
ofECMsaredecreasedbladdercapacityandpoorcomplianceafterimplantation.
Methodology/PrincipalFindings:Inthepresentexvivostudyanovelconceptwasinvestigatedwhereatwo-foldincrease
inECMscaffoldsurface-arearelativetotheresectedilealsegmentwascomparedinovinebladdermodelsafterAC.Results
showedthatbladdercapacityincreasedby4064%and37611%at10mmHgandcomplianceby40.464%and39.766%
(DP=0–10mmHg) after AC with ileum and porcine urinary bladder matrix (UBM) respectively (p,0.05). Comparative
assessmentbetweenileumandUBMdemonstratednosignificantdifferencesinbladdercapacityorcomplianceincreases
afterAC(p.0.05).
Conclusions:Thesefindingsmayhaveimportantclinicalimplicationsasmetabolic,infectiveandmalignantcomplications
precipitatedbymucus-secretingepitheliumarepotentiallyavoidedafteraugmentationwithECMscaffolds.
Citation: Davis NF, Mooney R, Callanan A, Flood HD, McGloughlin TM (2011) Augmentation Cystoplasty and Extracellular Matrix Scaffolds: An Ex Vivo
ComparativeStudywithAutogenousDetubularisedIleum.PLoSONE6(5):e20323.doi:10.1371/journal.pone.0020323
Editor:NielsOlsenSaraivaCa?mara, UniversidadedeSaoPaulo,Brazil
ReceivedFebruary25,2011;AcceptedApril22,2011;PublishedMay25,2011
Copyright: ? 2011 Davis et al. Thi
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