Autophagy-Related Atg8 Localizes to the Apicoplast of the Human Malaria Parasite Plasmodium falciparum 英文参考文献.docVIP
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Autophagy-Related Atg8 Localizes to the Apicoplast of the Human Malaria Parasite Plasmodium falciparum 英文参考文献
Autophagy-RelatedAtg8LocalizestotheApicoplastof
theHumanMalariaParasitePlasmodiumfalciparum
KeiKitamura1,2,ChiekoKishi-Itakura1,TakafumiTsuboi3,ShigeharuSato4,KiyoshiKita5,NobuoOhta2*,
NoboruMizushima1*
1DepartmentofPhysiologyandCellBiology,TokyoMedicalandDentalUniversity,Tokyo,Japan,2DepartmentofEnvironmentalParasitology,TokyoMedicalandDental
University,Tokyo,Japan,3Cell-FreeScienceandTechnologyResearchCenterandVentureBusinessLaboratory,EhimeUniversity,Matsuyama,Ehime,Japan,4Divisionof
Parasitology,MRCNationalInstituteforMedicalResearch,London,UnitedKingdom,5DepartmentofBiomedicalChemistry,GraduateSchoolofMedicine,TheUniversity
ofTokyo,Tokyo,Japan
Abstract
Autophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins.
AlthoughAtgproteinsarehighlyconservedineukaryotes,protozoapossessonlyapartialsetofAtgproteins.Nonetheless,
almostallprotozoahavethecompletefactorsbelongingtotheAtg8conjugationsystem,namely,Atg3,Atg4,Atg7,and
Atg8. Here, we report the biochemical properties and subcellular localization of the Atg8 protein of the human malaria
parasite Plasmodium falciparum (PfAtg8). PfAtg8 is expressed during intra-erythrocytic development and associates with
membraneslikelyasalipid-conjugatedform.FluorescencemicroscopyandimmunoelectronmicroscopyshowthatPfAtg8
localizes to the apicoplast, a four membrane-bound non-photosynthetic plastid. Autophagosome-like structures are not
observedintheerythrocyticstages.Thesedatasuggestthat,althoughPlasmodiumparasiteshavelostmostAtgproteins
duringevolution,theyusetheAtg8conjugationsystemfortheuniqueorganelle,theapicoplast.
Citation:KitamuraK,Kishi-ItakuraC,TsuboiT,SatoS,KitaK,etal.(2012)Autophagy-RelatedAtg8LocalizestotheApicoplastoftheHumanMalariaParasite
Plasmodiumfalciparum.PLoSONE7(8):e42977.doi:10.1371/journal.pone.0042977
Editor:TobiasSpielmann,BernhardNochtInstituteforTropicalMedicine,Germany
ReceivedJanuary30,2012;AcceptedJuly16,2012;PublishedAugust10,2012
Copyright: ? 2012
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