How To Record a Million Synaptic Weights in a Hippocampal Slice 英文参考文献.docVIP

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How To Record a Million Synaptic Weights in a Hippocampal Slice 英文参考文献.doc

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How To Record a Million Synaptic Weights in a Hippocampal Slice 英文参考文献

HowToRecordaMillionSynapticWeightsina HippocampalSlice UpinderS.Bhalla* NationalCentreforBiologicalSciences,TataInstituteofFundamentalResearch,Bangalore,India Abstract A key step toward understanding the function of a brain circuit is to find its wiring diagram. New methods for optical stimulationandopticalrecordingofneuronsmakeitpossibletomapcircuitconnectivityonaverylargescale.However, singlesynapsesproducesmallresponsesthataredifficulttomeasureonalargescale.HereIanalyzehowsinglesynaptic responses may be detectable using relatively coarse readouts such as optical recording of somatic calcium. I model a networkconsistingof10,000inputaxonsand100CA1pyramidalneurons,eachrepresentedusing19compartmentswith voltage-gated channels and calcium dynamics. As single synaptic inputs cannot produce a measurable somatic calcium response, I stimulate many inputs as a baseline to elicit somatic action potentials leading to a strong calcium signal. I comparestatisticsofresponseswithorwithoutasingleaxonalinputridingonthisbaseline.ThroughsimulationsIshow thatasingleadditionalinputshiftsthedistributionofthenumberofoutputactionpotentials.Stochasticresonancedueto probabilisticsynapticreleasemakesthisshifteasiertodetect.With,80stimulusrepetitionsthisapproachcanresolveupto 35%ofindividualactivatedsynapseseveninthepresenceof20%recordingnoise.Whilethetechniqueisapplicableusing conventional electrical stimulation and extracellular recording, optical methods promise much greater scaling, since the number of synapses scales as the product of the number of inputs and outputs. I extrapolate from current high-speed opticalstimulationandrecordingmethods,andshowthatthisapproachmayscaleuptotheorderofamillionsynapsesina singletwo-hourslice-recordingexperiment. Citation:BhallaUS(2008)HowToRecordaMillionSynapticWeightsinaHippocampalSlice.PLoSComputBiol4(6):e1000098.doi:10.1371/journal.pcbi.1000098 Editor:OlafSporns,IndianaUniversity,UnitedStatesofAmerica ReceivedDecember10,2007;AcceptedMay15,2008;Pub