Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung 英文参考文献.docVIP

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Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung 英文参考文献.doc

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Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung 英文参考文献

AbdullahandGoldmannDiagnosticPathology2012,7:158 /content/7/1/158 RESEARCH OpenAccess Pulmonaryhaptoglobin(pHp)ispartofthe surfactantsysteminthehumanlung MahdiAbdullahandTorstenGoldmann* Abstract:SincetheexistenceofpHpwasdemonstrated,ithasbeenshownthatthismoleculeanditsreceptor CD163areregulatedbydifferentstimuli.Furthermore,acomparablyfastsecretionofpHpwasdescribedaswellas theimmuno-stimulatoryeffects.TheintentionofthisstudywastoelucidatetheroleofpHpinthehumanlungs further.Hereweshow,bymeansofconfocalmicroscopyandimmune-electron-microscopy,aclearco-localization ofpHpwithSurfactantprotein-BinlamellarbodiesofAlveolarEpithelialCellsTypeII.Theseresultsareunderlined byimmunohistochemicalstainingsindifferentlyfixedhumanlungtissues,whichshowpHpinvesicularand releasedform.Theimagesofthereleasedformresembletheintendedpositionofsurfactantinthehumanalveolus. pHpissecretedbyAlveolarepithelialcellstypeIIaspreviouslyshown.Moreover,pHpisco-localizedwith Surfactantprotein-B.WeconcludethatthepresenteddatashowsthatpHpisanativepartofthesurfactantsystem inthehumanlung. Virtualslides:http://www.diagnosticpathology.diagnomx.eu/vs/2563584738239912. Keywords:Haptoglobin,Lung,Surfactant,Protein Background after ten minutes of stimulation, which is by far faster We recently reported that the plasma protein haptoglo- than the most other immuno-regulatory systems in the bin(Hp)isalsosynthesizedandexpressedinthehuman lung e.g. Toll-like receptor mediated signaling. It has lung[1].WedescribedexpressionofHp-proteininLung been shown that A549 cells release Interleukin-8 and cancer(mainlyinAdenocarcinomasofthelung),Alveo- monocyte chemotactic protein-1 upon co-stimulation larEpithelialCellstypeII(AECII),alveolarmacrophages with Hp and LPS, and monocyte derived macrophages and bronchial epithelia. The synthesis of pulmonary Hp releaseTNF-α, Interleukin-6 and monocyte chemotactic (pHp) was discovered in screening experiments with protein-1uponstimulationwithHp[1].Thismeans