Putting the bio into bioinformatics 英文参考文献.docVIP

Meeting report Putting the ‘bio’ into bioinformatics Olga G Troyanskaya Address: Department of Computer Science and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Washington Road, Princeton, NJ 08544, USA. E-mail: ogt@ Published: 29 September 2005 Genome Biology 2005, 6:351 (doi:10.1186/gb-2005-6-10-351) The electronic version of this article is the complete one and can be found online at /2005/6/10/351 ? 2005 BioMed Central Ltd more likely to occur in relatively short fragile areas of the A report on the 13th Annual Conference on Intelligent chromosomes. In the area of gene regulation, Wei Li (Dana- Systems for Molecular Biology (ISMB), Detroit, USA, 25-29 Farber Cancer Institute and Harvard School of Public June 2005. Health, Boston, USA) reported a new method based on hidden Markov models (HMMs) for analyzing chromatin immunoprecipitation-microarray experiments (ChIP-chip) The annual meeting on computational methods for molecu- lar biology brought together 1,731 attendees and covered a diversity of topics from sequence analysis and text mining to structural bioinformatics and pathway prediction. This year saw an increased emphasis on the biological problems that bioinformatic methods are being developed to solve; in addi- tion to many novel developments in traditional areas of bioinformatics, a substantial number of talks focused on integrative approaches, pathway analysis, and comparative genomics. Also on the menu this year were ways of making bioinformatic methods more ‘data-centric’ and how to make new technologies easily accessible to biologists. based on tiling arrays, and its use to identify binding sites for the transcription factor p53. The closer integration of bioinformatics and biology is also reflected in methods that incorporate known biological information into bioinformatic analyses. One such approach was highli