Quantitative pinch stimulator for exploring evoked nociceptive responses A pilot study 英文参考文献.docVIP

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Quantitative pinch stimulator for exploring evoked nociceptive responses A pilot study 英文参考文献.doc

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Quantitative pinch stimulator for exploring evoked nociceptive responses A pilot study 英文参考文献

Chenetal.BioMedicalEngineeringOnLine2010,9:79 /content/9/1/79 RESEARCH OpenAccess Quantitativepinchstimulatorforexploring evokednociceptiveresponses:Apilotstudy Chih-PingChen1,Wen-LiLiao1,Yi-LiTseng1,Pen-LiLu1,Yu-ChunLo1,You-YinChen2,Fu-ShanJaw1* *Correspondence:jaw@.tw 1InstituteofBiomedical Abstract Engineering,Collegeof EngineeringandCollegeof Medicine,NationalTaiwan Background:Amechanicalnoxiousstimulatorisusefulforstudiesofpain,bothfor clinicandbasicresearch.Weproposetouseapinchstimulatorthatcannotonly University,Taipei,Taiwan generateaquantitative,reproduciblenoxiouspinchbutalsosimultaneouslyprovide asynchronousexternaltriggersignal,whichisessentialforacquisitionofevoked potentials. Methods:Forethicalconsiderations,audibleandvisualaidswereincorporatedso thatpinchforcecouldberegulatedwithinapredeterminedlevel.Reproducibilityof thenociceptiveresponsesevokedbythisdevicewasvalidated.Thedevicewas constructedwithasimplecircuit,andtheelementbuild-inwasdelicatelyselected fortheminimumrequiredtoproduceevokedpotentials. Results:Themagnitudeoftheforceoutputislinearlyproportionaltothevolts producedbythedevice(i.e.,duringthepinch).Increasesinforcecorrespondto increasesinthenumberofactionpotentialsinduced. Conclusions:Thisdevicemaybeusefulforstudyingthemechanismsofnociceptive signalprocessinginthebrainthroughapplicationofreproducible,noxiouspinch stimuli. Background Nociceptionisaprimitivesensethatplaysanimportantroleinprotectingorganisms fromdangerousconditions. However,manyresearchers haveencountereddifficulties in studying nociception, due to lacking of appropriate noxious stimulators that can induceareproducible painsensation. Electrical stimulators arecommonlyused [1,2] becausetheyareeasytosynchronize.However,electricalstimulationwillactivatevar- ious types of nerve fibers, which results in ambiguous sensation. CO2 laser hasbeen used as specifically noxious heat stimulation [3]. However, nociceptive responses inducedarenotthesameastheresponsesevokedbymechanicalpin