Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites 英文参考文献.docVIP

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Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites 英文参考文献.doc

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Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites 英文参考文献

Open Access Re rch 2008FothetVoal.lumesea9, Issue 12, Article R177 Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites Bernardo J Foth, Neng Zhang, Sachel Mok, Peter R Preiser and Zbynek Bozdech Address: School of Biological Sciences, Nanyang Technological University, Nanyang Drive, 637551 Singapore. Correspondence: Zbynek Bozdech. Email: zbozdech@.sg Published: 17 December 2008 Received: 19 September 2008 Revised: 1 December 2008 Accepted: 17 December 2008 Genome Biology 2008, 9:R177 (doi:10.1186/gb-2008-9-12-r177) The electronic version of this article is the complete one and can be found online at /2008/9/12/R177 ? 2008 Foth et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ProteinelpectAroqpuexpressionhaonrteistaist rveevteprofilingiamlse-scigonuirfinsiceaPlasmodiumanalysisnt post-tofraproteinnscriptiabundanceonal regulatforionPlasmodium./p falciparum schizonts using two-dimensional differential gel Abstract Background: Malaria is a one of the most important infectious diseases and is caused by parasitic protozoa of the genus Plasmodium. Previously, quantitative characterization of the P. falciparum transcriptome demonstrated that the strictly controlled progression of these parasites through their intra-erythrocytic developmental cycle is accompanied by a continuous cascade of gene expression. Although such analyses have proven immensely useful, the correlations between abundance of transcripts and their cognate proteins remain poorly characterized. Results: Here, we present a quantitative time-course analysis of relative protein abundance for schiz