Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms 英文参考文献.docVIP

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Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms 英文参考文献.doc

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Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms 英文参考文献

Available online /content/10/4/R97 Research article Open Access Vol 10 No 4 Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms Annie George-Chandy1,2, Estelle Trysberg3 and Kristina Eriksson1 1Department of Rheumatology and Inflammation Research, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden 2Department of Infection Immunology, Statens Serum Institut, Artillerivej 5, 232 300 Copenhagen, Denmark 3Rheumatogy Unit at Karolinska University Hospital/Huddinge, H?lsov?gen 141, 141 52 Huddinge, Sweden Corresponding author: Annie George-Chandy, annie.george.chandy@microbio.gu.se Received: 2 Apr 2008 Revisions requested: 29 Apr 2008 Revisions received: 28 Jul 2008 Accepted: 22 Aug 2008 Published: 22 Aug 2008 Arthritis Research Therapy 2008, 10:R97 (doi:10.1186/ar2484) This article is online at: /content/10/4/R97 ? 2008 George-Chandy et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The tumour necrosis factor (TNF) family ligands BAFF (B-cell activating factor of TNF family) and APRIL (a proliferation-inducing ligand) are essential for B-cell survival and function. Elevated serum levels of BAFF and APRIL have been reported earlier in patients with systemic lupus erythematosus (SLE). Since autoantibody formation in the central nervous system (CNS) is a distinct feature of neuropsychiatric SLE (NPSLE), we have investigated whether NPSLE is associated with an enhanced intrathecal production of APRIL and BAFF. Separate analyses of SLE patients with and without CNS involvement revealed that NPSLE patients had enhanced levels of APRIL in CSF. BAFF and APRIL were likely produced locally in the CNS