RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma 英文参考文献.docVIP

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RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma 英文参考文献.doc

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RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma 英文参考文献

RNAInhibitionHighlightsCyclinD1asaPotential TherapeuticTargetforMantleCellLymphoma ShiriWeinstein1,2,RafiEmmanuel1,2,AshleyM.Jacobi3,AvigdorAbraham4,MarkA.Behlke3, AndrewG.Sprague5,TatianaI.Novobrantseva5,ArnonNagler4,DanPeer1,2* 1LaboratoryofNanoMedicine,DepartmentofCellResearchandImmunology,GeorgeS.WiseFacultyofLifeSciences,TelAvivUniversity,TelAviv,Israel,2Centerfor Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel, 3Integrated DNA Technologies, Inc., Coralville, Iowa, United States of America, 4Division of Hematology,ChaimShebaMedicalCenter,TelHashomer,Israel,5AlnylamPharmaceuticals,Cambridge,Massachusetts,UnitedStatesofAmerica Abstract Mantlecelllymphoma ischaracterized byagenetictranslocationresultsinaberrantoverexpressionoftheCCND1gene, whichencodescyclinD1.Thisproteinfunctionsasaregulatorofthecellcycleprogression,henceisconsideredtoplayan importantroleinthepathogenesisofthedisease.Inthisstudy,weusedRNAinterferencestrategiestoexaminewhether cyclinD1mightserveasatherapeutictargetformantlecelllymphoma.KnockingdowncyclinD1resultedinsignificant growthretardation,cellcyclearrest,andmostimportantly,inductionofapoptosis.TheseresultsmarkcyclinD1asatarget formantlecelllymphomaandemphasizethetherapeuticpotentialhiddeninitssilencing. Citation:WeinsteinS,EmmanuelR,JacobiAM,AbrahamA,BehlkeMA,etal.(2012)RNAInhibitionHighlightsCyclinD1asaPotentialTherapeuticTargetfor MantleCellLymphoma.PLoSONE7(8):e43343.doi:10.1371/journal.pone.0043343 Editor:AlfredLewin,UniversityofFlorida,UnitedStatesofAmerica ReceivedMarch22,2012;AcceptedJuly19,2012;PublishedAugust14,2012 Copyright: ? 2012 Weinstein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbygrantsfromtheLewisFamilyTrustandIsraelScienceFoundation(.il)(Award#181/10)toDP.Thefundershad noroleinstudydesign,