Sarcoidosis and Tuberculosis Cytokine Profiles Indistinguishable in Bronchoalveolar Lavage but Different in Blood 英文参考文献.docVIP

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Sarcoidosis and Tuberculosis Cytokine Profiles Indistinguishable in Bronchoalveolar Lavage but Different in Blood 英文参考文献.doc

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Sarcoidosis and Tuberculosis Cytokine Profiles Indistinguishable in Bronchoalveolar Lavage but Different in Blood 英文参考文献

SarcoidosisandTuberculosisCytokineProfiles: IndistinguishableinBronchoalveolarLavagebut DifferentinBlood MuhunthanThillai1,ChristianEberhardt1,AlexM.Lewin2,LeePotiphar1,SuzieHingley-Wilson1, SaranyaSridhar1,JonathanMacintyre1,OnnMinKon3,MelissaWickremasinghe3,AtholWells4, MarkE.Weeks5,DonaldMitchell4,AjitLalvani1* 1Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2Biostatistics Group, Department of EpidemiologyandPublicHealth,ImperialCollegeLondon,London,UnitedKingdom,3DepartmentofRespiratoryMedicine,St.Mary’sHospital,London,UnitedKingdom, 4InterstitialLungUnit,RoyalBromptonHospital,ImperialCollegeLondonNHSHealthcareTrust,London,UnitedKingdom,5MolecularHaematologyandCancerBiology Unit,UCLInstituteofChildHealth,London,UnitedKingdom Abstract Background:Theclinical,radiologicalandpathologicalsimilaritiesbetweensarcoidosisandtuberculosiscanmakedisease differentiationchallenging.Acomplicatingfactoristhatsomecasesofsarcoidosismaybeinitiatedbymycobacteria.We hypothesisedthatimmunologicalprofilingmightprovideinsightintoapossiblerelationshipbetweenthediseasesorallow ustodistinguishbetweenthem. Methods: We analysed bronchoalveolar lavage (BAL) fluid in sarcoidosis (n=18), tuberculosis (n=12) and healthy volunteers(n=16).Wefurtherinvestigatedserumsamplesinthesamegroups;sarcoidosis(n=40),tuberculosis(n=15)and healthy volunteers (n=40). A cross-sectional analysis of multiple cytokine profiles was performed and data used to discriminatebetweensamples. Results:WefoundthatBALprofileswereindistinguishablebetweenbothdiseasesandsignificantlydifferentfromhealthy volunteers. Insera, tuberculosis patients had significantly lower levelsof theTh2cytokine interleukin-4 (IL-4) thanthose with sarcoidosis (p=0.004). Additional serum differences allowed us to create a linear regression model for disease differentiation(within-sampleaccuracy91%,cross-validationaccuracy73%). Conclusions: These data warrant replication in in