Spatial Dimensions of Dengue Virus Transmission across Interepidemic and Epidemic Periods in Iquitos, Peru (1999–2003) 英文参考文献.docVIP

SpatialDimensionsofDengueVirusTransmissionacross InterepidemicandEpidemicPeriodsinIquitos,Peru (1999–2003) KellyA.Liebman1*,StevenT.Stoddard1,2,AmyC.Morrison1,3,ClaudioRocha3,SharonMinnick1 ,Moises Sihuincha4,KevinL.Russell3,JamesG.Olson3,PatrickJ.Blair3,DouglasM.Watts5,TadeuszKochel3, ThomasW.Scott1,2 1 Department of Entomology, University of California Davis, Davis, California, United States of America, 2 Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America,3 Naval Medical Research Center Detachment, Washington D.C., United States of America,4 Hospital de Apoyo de Iquitos, Regio′n Loreto, Peru′ ,5 University of Texas at El Paso, El Paso, Texas, United States of America Abstract Background: Knowledge of spatial patterns of dengue virus (DENV) infection is important for understanding transmission dynamics and guiding effective disease prevention strategies. Because movement of infected humans and mosquito vectors plays a role in the spread and persistence of virus, spatial dimensions of transmission can range from small household foci to large community clusters. Current understanding is limited because past analyses emphasized clinically apparent illness and did not account for the potentially large proportion of inapparent infections. In this study we analyzed both clinically apparent and overall infections to determine the extent of clustering among human DENV infections. Methodology/Principal Findings: We conducted spatial analyses at global and local scales, using acute case and seroconversion data from a prospective longitudinal cohort in Iquitos, Peru, from 1999–2003. Our study began during a period of interepidemic DENV-1 and DENV-2 transmission and transitioned to epidemic DENV-3 transmission. Infection status was determined by seroconversion based on plaque neutralization tes