An Efficient Synthesis of Pyrazolo[3,4-b]quinolin-3-amine and Benzo[b][1,8]naphthyridine Derivatives.docVIP

Molecules 2007, 12, 361-372 molecules ISSN 1420-3049 Full Paper An Efficient Synthesis of Pyrazolo[3,4- b]quinolin-3-amine and Benzo[b][1,8]naphthyridine Derivatives Yehya M. Elkholy Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt; E-mail: y_elkholy@ Received: 24 January 2007; in revised form: 10 February 2007 / Accepted: 21 February 2007 / Published: 8 March 2007 Abstract: 2-Oxo-4-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (10) reacted with hydrazine hydrate, phenylisothiocyanate or benzoyl chloride to give derivatives 12, 13 and 15