Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples a promising tool for early detection of COPD and lung cancer in smokers.docVIP

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Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples a promising tool for early detection of COPD and lung cancer in smokers.doc

Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples a promising tool for early detection of COPD and lung cancer in smokers

Guzmánetal.DiagnosticPathology2012,7:87 /content/7/1/87 RESEARCH OpenAccess Analysisofaberrantmethylationonpromoter sequencesoftumorsuppressorgenesandtotal DNAinsputumsamples:apromisingtoolfor earlydetectionofCOPDandlungcancerin smokers LedaGuzmán1*,MaríaSoledadDepix2,AnaMaríaSalinas2,RosaRoldán3,FranciscoAguayo4,AlejandraSilva2 andRaulVinet5,6 Abstract Background:Chronicobstructivepulmonarydisease(COPD)isadisorderassociatedtocigarettesmokeandlung cancer(LC).Sinceepigeneticchangesinoncogenesandtumorsuppressorgenes(TSGs)areclearlyimportantinthe developmentofLC.Inthisstudy,wehypothesizethattob

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Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples a promising tool for early detection of COPD and lung cancer in smokers.docVIP