原创力文档Analysis of hypermethylation and expression profiles of APC and ATM genes in patients with oral squamous cell carcinoma.docVIP
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Analysis of hypermethylation and expression profiles of APC and ATM genes in patients with oral squamous cell carcinoma
Rigi-Ladizetal.ClinicalEpigenetics2011,3:6
/content/3/1/6
RESEARCH
OpenAccess
Analysisofhypermethylationandexpression
profilesofAPCandATMgenesinpatientswith
oralsquamouscellcarcinoma
MohammadAyubRigi-Ladiz1,DorMohammadKordi-Tamandani2* andAdamTorkamanzehi2
Abstract
Background:Adenomatouspolyposiscoli(APC)andAtaxia-telangiectasia-mutated(ATM)geneproductshavean
importantroleincellcyclecontrolandmaintenanceofgenomicstability.OuraimwastoanalyzeATMandAPC
methylationanditsrelationshipwithoralsquamouscellcarcinoma(OSCC).
Materialsandmethods:Eighty-fourOSCCtissuesthathavebeenfixedinparaffinalongwith
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