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Analysis of variation at transcription factor binding sites in Drosophila and humans
Spivakovetal.GenomeBiology2012,13:R49
/2012/13/9/R49
RESEARCH
OpenAccess
Analysisofvariationattranscriptionfactor
bindingsitesinDrosophilaandhumans
MikhailSpivakov1,2*,JunaidAkhtar2,PouyaKheradpour3,4,KathrynBeal1,CharlesGirardot2,GautierKoscielny1,
JavierHerrero1,ManolisKellis3,4,EileenEMFurlong2andEwanBirney1*
Abstract
Background:Advancesinsequencingtechnologyhaveboostedpopulationgenomicsandmadeitpossibleto
mapthepositionsoftranscriptionfactorbindingsites(TFBSs)withhighprecision.HereweinvestigateTFBS
variabilitybycombiningtranscriptionfactorbindingmapsgeneratedbyENCODE,modENCODE,ourpreviou
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