Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens.docVIP

Available online /content/7/5/R938 Research article Open Access Vol 7 No 5 Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens Martin Schmidt1*, Claudia Weidler2*, Heidrun Naumann1, Sven Anders3, Jürgen Sch?lmerich2 and Rainer H Straub2 1Institute of Biochemistry II, Hospital of the Friedrich-Schiller-University, Jena, Germany 2Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany 3Department of Orthopedic Surgery