Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity.docVIP

Davisetal.CriticalCare2010,14:R89 /content/14/3/R89 RESEARCH OpenAccess Angiopoietin-2isincreasedinsepsisand inverselyassociatedwithnitricoxide-dependent microvascularreactivity JoshuaSDavis1,2,TsinWYeo1,KimAPiera1,ToniaWoodberry1,DavidSCelermajer3,DiannePStephens4, NicholasMAnstey1,2* Abstract Introduction:Angiopoietin-2(ang-2),anangiogenicpeptidereleasedbyendothelialcellWeibel-Paladebodies (WPBs),increasesendothelialactivationandvascularpermeability.Ang-2israisedinseveresepsisbutthe mechanismsunderlyingthisarenotknown.Nitricoxide(NO)inhibitsWPBexocytosis,andbioavailabilityof endothelialNOi