原创力文档Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis.docVIP
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Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis
Alfierietal.CriticalCare2012,16:R182
/content/16/5/R182
RESEARCH
OpenAccess
Angiopoietin-1variantreducesLPS-induced
microvasculardysfunctioninamurinemodel
ofsepsis
AlessioAlfieri1*,JayJWatson1,RichardAKammerer2,MohammedTasab3,PavlosProgias3,KimberlyReeves1,
NicolaJBrown1?andZoeLBrookes1?
Abstract
Introduction:Severesepsisischaracterisedbyintravascularorextravascularinfectionwithmicrobialagents,
systemicinflammationandmicrocirculatorydysfunction,leadingtotissuedamage,organfailureanddeath.The
growthfactorangiopoietin(Ang-1)hastherapeuticpotentialbutrecombinantAng-1tendstoaggregateandhasa
short
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