Anti-inflammation effects of picroside 2 in cerebral ischemic injury rats.docVIP

Guo et al. Behavioral and Brain Functions 2010, 6:43 /content/6/1/43 RESEARCH Open Access Anti-inflammation effects of picroside 2 in cerebral Research ischemic injury rats Yunliang Guo*1, Xinying Xu1, Qin Li1,2, Zhen Li1,3 and Fang Du1 Abstract Background: Excitatory amino acid toxicity, oxidative stress, intracellular calcium overload, as well as inflammation and apoptosis are involved in the pathological process after cerebral ischemic reperfusion injury. Picrodide 2 could inhibit neuronal apoptosis and play anti-oxidant and anti-inflammation role in cerebral ischemia/reperfusion injuri