Anti-immunoglobulin E therapy.docVIP

REVIEWARTICLE AntiYImmunoglobulinETherapy ManavSegal,JeffreyR.StokesandThomasB.Casale leukotrienemodi?ersandanti-histamines)or theuseofcor- Abstract: The importance of immunoglobulin E (IgE) in atopic disorderssuchasasthma,allergicrhinitis,foodallergies,andatopic dermatitis is well established. Elevation of total serum IgE is typi- callyfoundinmanyatopicpatients,andinpredisposedindividuals, allergen-speci?c IgE is produced. The availability of humanized monoclonal antibodies against IgE has provided a new therapeutic option andtool toexplore theroleIgEinallergicdiseasesandthe effectsof inh