Antifungal activity of redox-active benzaldehydes that target cellular antioxidation.docVIP

Kimetal.AnnalsofClinicalMicrobiologyandAntimicrobials2011,10:23 /content/10/1/23 RESEARCH OpenAccess Antifungalactivityofredox-activebenzaldehydes thattargetcellularantioxidation JongHKim,KathleenLChan,NoreenMahoneyandBruceCCampbell* Abstract Background:Disruptionofcellularantioxidationsystemsshouldbeaneffectivemethodforcontroloffungal pathogens.Suchdisruptioncanbeachievedwithredox-activecompounds.Naturalphenoliccompoundscanserve aspotentredoxcyclersthatinhibitmicrobialgrowththroughdestabilizationofcellularredoxhomeostasisand/or antioxidationsystems.Theaimofthisstudywastoidentifybenzaldehyde