Antigen and Memory CD8 T Cells Were They Both Right.docVIP

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Antigen and Memory CD8 T Cells Were They Both Right.doc

Antigen and Memory CD8 T Cells Were They Both Right

ORIGINAL ARTICLE AntigenandMemoryCD8TCells:WereTheyBothRight? SlavaEpelman,MD,PhDandChristopherH.Mody,MD Pictureyourselfasaresearcherinimmunology.Tobeginyourproject,youaskaquestion:DoCD8Tcellsrequireantigentomaintain amemoryresponse?Thisquestionisofprimeimportancetonumerousmedicalfields.Inchronologicorder,youdigesttheliterature, butunfortunately,youhitamajorstumblingblockinthe1990s.Thecruxoftheproblemisthatwhichsooftenhappensinscience: two well-recognized, capable groups emerge with diametrically opposed conclusions, leaving you pondering which set of well- controlleddatatobelieve.Fortunatel

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