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Antigen and Memory CD8 T Cells Were They Both Right
ORIGINAL ARTICLE
AntigenandMemoryCD8TCells:WereTheyBothRight?
SlavaEpelman,MD,PhDandChristopherH.Mody,MD
Pictureyourselfasaresearcherinimmunology.Tobeginyourproject,youaskaquestion:DoCD8Tcellsrequireantigentomaintain
amemoryresponse?Thisquestionisofprimeimportancetonumerousmedicalfields.Inchronologicorder,youdigesttheliterature,
butunfortunately,youhitamajorstumblingblockinthe1990s.Thecruxoftheproblemisthatwhichsooftenhappensinscience:
two well-recognized, capable groups emerge with diametrically opposed conclusions, leaving you pondering which set of well-
controlleddatatobelieve.Fortunatel
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